Today  March,  2015.    We update daily.  We welcome you to the Chios  Mastiha / Mastic Gum  World…

e-mail :

masticbest@gmail.com        general   questions

mastihainfo@gmail.com      best  mastiha  orders

bestmastiha@gmail.com       organic  mastiha orders

mastiha10@gmail.com        wholesale  orders export

mastiha100@gmail.com        retail    orders  export

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mastiha - mastic gum - online-shop

best price mastiha – mastic gum – online-shop  mastihainfo@gmail.com

If you would like to make a purchase from us you can simply contact us + 30 69 94 70 50 40  or alternatively e-mail us at  masticbest@gmail.com    or   mastihainfo@gmail.com  for PayPal orders
Your order will be processed and dispatched during working hours to your desired address where you will have to sign for the parcel. NOTE :  Paypal delays payment 3 – 9 days into our account.    We will post to anywhere in the world, obviously depending on where you are will effect the postage price, but we will make you aware of this before processing your order.


order e mail : mastihainfo@gmail.com

. ALL PRICES ARE IN EURO.    .    .   http://onlinefx.westernunion.com/currency-calculator/

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 Some of  Our Product  List

Update – 8 a.m. Today 2015      NOTE : SEND E MAIL TO GET OUR WHOLESALE  PRICES   mastihainfo@gmail.com  – – same e mail for PayPal Orders 

SKU  101  Small Mastiha Tears 10g  NOW  € 1.49 OR LESS

SKU  102  Medium Mastiha Tears 10g

SKU  103  Small Mastiha Tears 20g    NOTE :  We can beat any price anywhere

SKU  104  Medium Mastiha Tears 20g      NOTE :  We can beat any price anywhere

SKU  105  Small Mastiha Tears 50g

SKU  106  Medium Mastiha Tears 50g

SKU  107  Small Mastiha Tears 100 g     NOTE :  We can beat any price anywhere

SKU  108  Medium Mastiha Tears 100 g      NOTE :  We can beat any price anywhere

SKU  109  Large Mastiha Tears 100 g        NOTE :  We can beat any price anywhere NOW € 12.99 OR LESS

SKU  200  Small   Mastiha Tears 500 g

SKU  201  Medium Mastiha Tears 500 g

SKU  202  Large Mastiha Tears 500 g

SKU  203  Fresh Medium Tears 500 g

SKU  204  Fresh Large Tears 500 g

SKU  206 Fresh Chios Mastic Gum AAA best Quality Bulk.  Orders  over 5 Kilograms  or more send e mail for wholesale  prices mastihainfo@gmail.com

SKU 210 Fresh Chios Mastic Gum AAA best Quality Bulk .  Best price for 15 kilograms or more send e mail.


mastiha-small 10g

best mastiha-small 10g  best mastiha-medium 10g


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best chios mastiha various sizes – 10 g, 20 g, 50 g, 100 g, 500 g


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best chios mastic gum wholesale price list 2015


Chios Mastiha is a unique product with many beneficial qualities and wide- ranging uses since antiquity. Nowadays, it is used in pharmaceuticals, perfumes, cosmetics, beverages, bakery goods, sweets as well as in cooking. Chios Mastiha is the natural resin of pistacia lentiscus var. Chia, a tree which grows only on the Aegean island of Chios, Greece. Scientific research shows that Chios Mastiha has anti- microbial, anti- inflammatory, and healing activity. Also, it has beneficial effects on both body hygiene and skin care.

SKU  205  Chios Mastiha Cooking Powder  50 g

SKU  206  Chios Mastiha Nutritional Powder  50 g

SKU  207  Chios Mastiha Powder 100%  50 g

SKU  208  NEW –  BEST  Chios Mastiha Powder 100%   25 g      NOTE :  We can beat any price anywhere

SKU  301  Mastiha Therapy Nutritional Powder 50 g

SKU  302  Mastiha Therapy Medium Tears  20 g   NOW € 2.99  OR LESS

SKU  303  Mastiha Therapy Large Tears  20 g

SKU 304 Mastiha Therapy Large Tears 50 g

SKU 305 Mastiha Therapy Large Tears  100 g   – – – for  Best Price send e mail.

mastiha / mastic cooking powder

best chios mastiha / mastic cooking powder


chios mastiha nutritional supplement

best chios mastiha nutritional supplement


Mastiha Oil / Mastic Oil – FRESH and PURE
You will not find a higher quality mastiha essential oil anywhere!
We at mastic best and mastiha best doing the same  formula over and over again for many generations.
We use the steam-distills method to obtain the 100% natural  pure and FRESH Mastiha / Mastic oil  with no added chemicals or alchohol. –

Mastic Oil – Mastiha oil – Pure Mastic Oil – Chios Mastic oil
A unique natural product with many beneficial properties and a variety of uses well known since antiquity. Currently used in pharmaceutical, industrial perfumes and cosmetics the beverage industry, cooking and pastry. Mastic is a natural resin of the tree pistacia lentiscus var. Chia, which grows only on the island of Chios. According to scientific research or mastic has antimicrobial, anti-inflammatory and healing action with beneficial effects on oral hygiene, the function of the gastrointestinal system and skin care.

SKU  400  Chios Mastiha Essential Oil  100% pure   3 g   NOW € 14.99  OR LESS

SKU  401  Chios Mastiha Essential Oil  100% pure   5 g      NOTE :  We can beat any price anywhere

SKU  402  Chios Mastiha Essential Oil  100% pure  10 g

SKU  403  Chios Mastiha Essential Oil  100% pure  25 g

SKU  504  Chios Mastiha Essential Oil  100% pure  50 g      NOTE :  We can beat any price anywhere

SKU  505  Chios Mastiha Essential Oil  100% pure  100 g    for  Best Price send e mail.

4 new mastic oils are out in the market – free samples available you just pay only for shipping cost and handling


Mastiha Natural Flavor

Less concentrated than the essential oil, but still packed with the goodness of Chios Mastiha, this natural flavoring can be used in cooking, cosmetics, or for therapy.

SKU  602 a  Chios Mastiha Aroma  100% pure  5 g

SKU  603 a  Chios Mastiha Aroma  100% pure  10 g     NOTE :  We can beat any price anywhere

SKU  604 a  Chios Mastiha Aroma  100% pure  50 g     NOTE :  We can beat any price anywhere

SKU  605 a  Chios Mastiha Aroma  100% pure  100 g   for Best Price send e mail.

SKU  610  Chios Mastic Gum for Varnish use  –  send e mail for prices

Varnish – This is a protective “finish” or application for wood and other materials. Varnish is usually transparent or mostly transparent. It goes on wet and dries hard. It can have various levels of sheen (high gloss, glossy, semi-gloss, satin, etc.). Traditional varnishes contain an oil, a resin, and a solvent. The oils, also known as drying oils, harden after long exposure to oxygen. Examples of drying oils are linseed oil, poppy seed oil, tung oil, and walnut oil. Resins have been discussed at length above, and varnish resins include amber, copal, balsam, copaiba, elemi, CHIOS MASTIC GUM, rosin, and sandarac. The most common solvent, by far, is turpentine.

SKU  620  Chios Mastic Gum for lacquer use  –  send e mail for best prices

SKU 630 A NEW Chios Mastic Gum for lacquer use  now bulk orders available

Lacquer – This is a type or method of varnishing, but is typically treated separately. Most varnishes undergo a chemical reaction that causes the varnish to harden. However, lacquers only undergo evaporation. If the solvent is reapplied to the finish (i.e. the lacquer), it will soften again. The resin that is traditionally used to make lacquer is lac (you can see where the name comes from!). Lac is the secretion from the lac insects of Asia. The dried secretion is refined and cleaned with a few different methods and then dries into shellac flakes. These flakes are dissolved in a solvent (lacquer thinners or alcohols) to make liquid shellac. Modern lacquer uses synthetics like polyurethanes, acrylics, or alkyds. Because these lacquers do not contain lac, they are not called shellacs, just lacquers. Another difference between modern varnishes and lacquers is that modern lacquers/shellacs are sprayed on while varnishes are brushed on.

Hard Resins: These are, not surprisingly, hard. Here are some examples of hard resins:

    • Dammar – obtained from the Dipterocarpaceae family of lowland, tropical rainforest trees from around the globe and the Agathis trees of  southeast Asia and northern Australia. Dammar is used as a glaze for foods, crafts, incense, varnish, and more.
    • Mastic – obtained from the Chios Mastic Tree (Pistacia lentiscus Var. Chia). Mastic was commonly used as a natural chewing gum, but it is also used in ice creams, puddings, pastries, nougat, sauces, soups, fruit and vegetable preserves, soft drinks, coffee, liqueurs, and many other foods. It has a long history as a medicinal and incense, and is also used in perfumes and cosmetics and even in varnishes.
    • Sandarac – obtained from the Sandarac Tree (Tetraclinis articulata) of North Africa in a dry, Mediterranean climate. Sandarac is used for varnish and lacquer.

Chios Mastiha Water

Mastiha water is a natural aqueous extract of the Mastiha oil and softly retains the unique flavor of mastiha and some of the beneficial attributes as well. It is 100% natural and contains all the water-soluble ingredients of mastiha and therefore some of the beneficial qualities. In addition scientific studies has shown that some of the active ingredients of mastiha essential oil can also be found in mastiha water. However, it will be very interesting to further study whether or not mastiha water itself exhibits mastiha oil actions (anti-microbial, anti-bacterial). It is produced from a steam distillation of Chios Mastiha.

SKU  601  Mastiha Water Extra  50 ml

SKU  602  Mastiha Water Extra  250 ml   Best  Price anywhere  for 2015  mastiha10@gmail.com

SKU 603 Mastiha Water bulk at best price anywhere


fresh mastic oil

fresh mastic oil – best mastic oil – best price


Organic Extra Virgin olive Oil with Mastiha

Try our delicious and organic Extra Virgin Olive Oil  made with 0.5% mastiha, for a true mediterranean experience. The exotic and rich flavor makes it an excellent companion to any snack or meal.  Awarded for quality, taste and sleek packaging.

SKU  701  Extra Virgin Olive Oil with mastiha 50 ml, 100 ml, 200 ml

SKU  702  Organic Extra Virgin Olive Oil with  Mastiha  50 ml, 100 ml, 200 ml

SKU  703  Organic Extra Virgin Olive Oil with  Mastiha  500 ml,   for Best Price send e mail.


mastic best quality / mastiha best quality / best price guarantee only at https://masticbest.wordpress.com

Mastic Best Price / Mastiha Best Price – – You’re backed by our Best Price Guarantee.




Greek Coffee with Mastiha

Greek Loukoumakia mastihas with sugar

Mastiha spirits – ouzo mastihas – liqueur mastihas – tsipouro mastihas – mastiha spirits and herbs

mastiha leaves

best mastiha fresh

best mastiha fresh


Mastiha Names around the world  –


Mastiha is a natural product mysteriously found only on an eastern Mediterranean volcanic island [Chios, Greece] 3000 years ago.

Known since antiquity for its healing effects, Mastiha has been used as an excellent digestive & multifunctional medicament

Greeks, Romans, Byzantines, Genoese and Ottoman introduced it to the world throughout the ages & made it the true cosmopolitan Mediterranean product.

A precious product, Mastiha has always  been considered a luxury delicacy.

5th Century BC: Herodotus records Mastiha under its ancient name of “Skinos”. Hippocrates recommended it for its medicinal qualities as well as an excellent digestive and breath freshner.

The Roman Years; The Roman Emperor Heliogabalus spiced his wine with Mastiha oil to add aroma.

Byzantine years: Mastiha was declared the Emperor’s monopoly.
It was exported as a luxury product throughout the known world.

Genoan dominance: Mastiha trade flurished  both East and West. Constantinople, Rome, Paris, London, Alexandria, Damasus, Venice, Florence and Marseille were some of the many destinations.

Ottoman Empire: The highest quality from each crop was sent East to the Sultan’s harem. His numerous wives considered it a rare delicacy with mystical purification powers for body and soul.

Today: The journey continues! The modern spark of interest in natural, traditional products has once again made Mastiha a global product

Mastiha, the Therapeutic

Mastiha is known since antiquity for its healing effetcs while recent studies have sparked a widespread interest in it:

Hippocrates [500BC], the Father of  medicine used to mix Mastiha with honey to cure bellyaches & fight cold.

Dioscurides [100BC], doctor & herbalist, recognized Mastiha as extremely good for the stomach, the digestion & the teeth [gums & whitening effect].

Rebasius, Soranos the Ephesian, Etius Medicus, Scribonius Largus suggested numerous remedies with Mastiha.

The University of Nottingham revealed that even small quantities of Mastiha can cure peptic ulcers.


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(R) TM  –  mastiha best – mastic best


masticbest / mastihabest

masticbest / mastihabest  – (c)  mastiha tear R TM E.M.X.


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(C) https://masticbest.wordpress.com/ mastiha tear   R    TM   E.M.X.


mastiha buy direct

mastiha buy direct and SAVE




mastiha Nutritional Supplements

Parapharmaceuticals – Nutritional Supplements – Mastiha powder, Mastiha capsules


SKU  801  NEW  Handmade Fresh Halva Mastihatos with  Mastiha AAA  Special Price – 15%  from Reg. Price

SKU 802  Preserve  Fresh Mastiha / Mastic  300 g.   Best Price anywhere   –  Write


SKU  1001  Spirit   Mastiha  50 ml   1.30 euro

SKU 1002  Spirit  Mastiha n Herbs  50 ml  1.30 euro

SKU 1003  Spirit Mastiha n Μelograno  50 ml  1.30 euro



All orders over  500 euro  have  5%  DISCOUNT,  over a 1000 euro 10% .

Export Manager –  Steve Stamatis

Tel.    +  30 69 94 70 50 40          8 a.m. –  10 p.m.    7/365

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mastiha special offer

mastiha special offer – Buy Direct and save – BEST PRICE


Special Offers   for   Today  2015

Mastiha Oil  100% Pure  and FRESH   9.99 euro  Best Price – Best Product

Mastiha Powder 100% PURE and FRESH  9.99 euro  Best Price –  Best Product

Mastiha Water Fresh 0.99 euro  Best Price –  Best Product

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mastiha various types and sizes


Chios Mastiha  is a unique product with many beneficial qualities and wide- ranging uses since antiquity.   Nowadays, it is used in pharmaceuticals, perfumes, cosmetics, beverages, bakery goods, sweets as well as in cooking.   Chios Mastiha is the natural resin of pistacia lentiscus var. Chia, a tree which grows only on the Aegean island of Chios, Greece.   Scientific research shows that Chios Mastiha has anti- microbial, anti- inflammatory, and healing activity.   Also, it has beneficial effects on both body hygiene and skin care.

Important Note: Medium mastiha tears are quite soft. They are commonly used for coocking (after crashing the tears) and for chewing as well.
Mastiha and its products have great beneficial properties and activities supported by scientific findings and research:
  • Contributes to the hygiene of the gastrointestinal system
  • Exhibits therapeutic effect in patients suffering from peptic ulcers
  • Exhibits strong anti-microbial and antibacterial action
  • Exhibits healing and anti-inflammatory activity
  • Acts as a natural antioxidant agent
  • Makes a positive contribution to oral hygiene

Chios mastic gum side effects NONE, Mastic Gum Side Effects non available

Mastic Gum Side Effects NONE,Side Effects Of Mastic Gum  NONE,Helicobacter Pylori –  Mastic Gum Side Effects NONE,chios mastiha gum side effects none,


mastiha oil - mastic oil - mastiha best

Fresh  – BEST mastiha oil – BEST mastic oil

Chios Mastiha Essential Oil  –  You will not find a higher quality mastiha essential oil anywhere!!  –  The C M G A steam-distills the raw Chios mastiha themselves ensuring its 100% natural with no added chemicals or alchohol.   So use it sparingly in cooking and therapy, a drop goes a long way !!!

Now special prices for Chios Mastic Oil AAA quality fresh write masticbest@gmail.com

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mastiha oil flavor

BEST mastiha oil flavor

Less concentrated then the essential oil, but still packed with the goodness of Chios Mastiha, this natural flavoring can be used in cooking, for therapy, cosmetics, candle making, soap making, etc.  SKU F 5 = 5g,  SKU  f 10 = 10 g,    SKU  f 20 = 20 g,   SKU  f 50 = 50 g,    SKU f 100 = 100 g  or any other amount

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mastiha gum - chios mastic gum - chios mastiha

mastiha gum – chios mastic gum – chios mastiha

mastiha  small 10 g

mastiha 10 g small, medium tears

mastiha 2015  Portfolio – –  we  ship  DIRECT  WORLDWIDE


mastiha 2013 Portfolio

FRESH mastiha chewing gum

mastiha best elma box

mastiha best elma box – no longer in production



mastic mastiha specifications

mastic mastiha specifications 2015




mastiha mastic gum

mastiha mastic gum

.organic honey with mastiha

organic honey with mastiha


organic honey mastiha

organic honey  with  saffron


1.   Aromatic Olive Oil Soap with Chios Mastiha  –  Soap with natural, green color that is produced by 100% pure substances without the addition of artificial colors and other chemical additives. This natural olive oil soap combines the unique beneficial attributes of olive oil and the antimicrobial and antibacterial action of mastiha and mastiha oil, leaving the skin clean and soft. It is suggested for a very natural cleaning agent and has a positive action against psoriasis. Best if used in combination with the Body Milk with Chios Mastiha for clean and hydrated epidermis !

2.  Dark Chocolate Covered Mastiha Loukoums in a Metal Box   – A traditional smooth mastiha jelly delight (loukoumi) coated with thick dark chocolate. We upgraded the traditional mastiha loukoumi in a playful way replacing ice sugar with rich dark chocolate. The “bitterness” of dark chocolate balances out the sweet traditional loukoumi. A very tasty combination that adds a new dimension to a traditional Eastern Mediterranean snack. The metal tin is a beautiful carrying case for them and can be kept as a keepsake box. A truly exceptional gift !

3.  Dark Chocolate Covered Halva Bar with Mastiha  – Halva is produced from quality, natural ingredients and is regarded as one of the most nutritious and healthy natural food due to the high nutritional value of the basic ingredient sesame seeds. Nutritional analysis results show it to be an excellent source of protein and polyunsaturated fats, while being rich in vitamins and trace elements, such as iron and magnesium. The delicious flavour of Mastiha, coated with dark chocolate makes these halva bars a delicious and healthy snack.

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mastiha dental gum various

mastiha dental gum various – mastic gum various



mastiha spirits

mastiha spirits various – various mastiha liqueur  -



best mastiha greek product


mastiha order form

mastiha order form – pro forma invoice Greek






europe_WE NEED REPRESENTATIVES email mastihainfo@gmail.com


We update this blog  daily.                                                                                                                                                                     .

Page Created at  15  March  2010

Last  Modified :      Today  – 09:00 a.m.   2015

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Contact Us

If you have any questions regarding  Mastiha / Mastic and are still unsure if it is right for you, your question can be submitted to our support team at the support email listed below.

e-mail :

masticbest@gmail.com        general   questions

mastihainfo@gmail.com       best  mastiha  orders

bestmastiha@gmail.com       organic  mastiha orders

mastiha10@gmail.com        wholesale  orders export

mastiha100@gmail.com      retail    orders  export

Note :  We answer all our e mails within a day  –  delay time from 1 – 10 hours due to high traffic.  Free samples available you just pay for shipping and insurance we refund cost on first order.

Due to the large volume of emails, it is helpful if you can address your enquiry to the relevant department. We promise a same day response on all emails.

P.S.  We answer  your  emails  within the day – we offer  24 hour service

Or Call Us on  – 00 30 69 94 70 50 40     sms service avaiable 24 hours

.00  30  69 94 70 50 40 GMT+0300 (GTB Daylight Time)

From  8 a.m. – 10 p.m.       7 days  365/yr.

Registered  in  Greece.

All our products are  Made in Greece under very strict rules and regulations, to give you the best product available in the world market.  We ship  from Chios, and Athens.

First Class  Air Mail Registered  service  to all  our  export customers  abroad.


MAIN  OFFICE  :    CHIOS   GREECE    Tel.  00 30 69 94 70 50 40


.    Tel. 00 30 69 94 70 50 40 1

EUROPE  BRANCH        Tel.   00 30 69 94 70 50 40 2

NEW  YORK BRANCH    –  For  U.S.A. , and   CANADA

.    Tel.  00 30 69 94 70 50  40 3

SOUTH AMERICA BRANCH    Tel.  00 30 69 94 70 50 40 4

ASIA  BRANCH             Tel.  00 30 69 94 70 50 40 5

AFRICA  BRANCH         Tel.  00 30 69 94 70 50 40 6

AUSTRALIA  BRANCH    Tel.  00 30 69 94 70 50 40


Για οποιαδήποτε πληροφορία μπορείτε να επικοινωνήσετε μαζί μας…

στο  masticbest@gmail.com –  Τηλ. 00 30 69 94 70 50 40

Από  8 π.μ.  –  10 μ.μ    καθημερινά  +  Σαββ.  +  Κυριακή


P.S. Subscribe to our email newsletter and receive  our special  offers and news by email.


Privacy Statement .  The Masticbest is committed to protecting your privacy, including on the Masticbest’s  Page. We will not collect any personal information unless you provide that information to us.  Personal information includes your name, address, telephone number and e-mail address. Although we do not gather individually-identifiable information from visitors who navigate our site, we do use computer logs to count our visitors. We do not create individual profiles on our visitors or distribute any of our log information to other organizations.

Site Management  Masticbest  manages the overall information content, design, and, organization of the Web site.   Masticbest also coordinates release of  Masticbest information on the Internet.



 1)  Mastiha   Mastiha  B 


.                           2)  mastic  mastiha  







Videos will be uploaded  soon .


Cheaper   Product   Elsewhere  ?

If  you  happen  to find  the  same  product  elsewhere  cheaper,

please inform us  and  GET  IT   for  less  than  their  price  ! ! !





We accept  :

PAYPAL,  MONEY GRAM,  WESTERN UNION,  Bank Checks,  Bank Deposits,  Bank Money Orders.


Piraeus Bank  Branches in USA,  Great Britain, Cyprus,  Serbia,  Romania,  Ukraine,  Bulgaria,  Albania,  Egypt.  (Internet Banking – Phone &  mobile banking)

Piraeus Bank



paypall  e mail  mastihainfo@gmail.com



MoneyGram –  Money Transfer
masticbest pay pal

masticbest      mastihainfo@gmail.com





greek postal service

Contact Us :
We always welcome your questions and comments.
If you wish to make an order or product inquiry over the phone:
US customers please call:  00 30 69 94 7050 40
International callers please call:  00 30 69 94 70 50 40

Our Customer Service Department is available  seven days a week:
From 8:00am – 10:00pm

If you have a question about  :  Site Use,  Shipping & Handling,  Wholesale Orders, or Volume Discounts,  please write to us   masticbest@gmail.com


Shipping  & handling  charges.
All orders up to € 100.00, First Class  Registered  Mail,  €  24
over  € 100.00, First Class  Registered  Mail, € 29
Orders from   over  € 300.00, First Class  Registered  Mail, € 39
 Orders over €  500.00 or more get Special Low price – 65% Discount or  € 49


We are actively looking for retailers WORLDWIDE  to stock our products please contact us at   mastiha100@gmail.com for more information.


Phone and postal contact

If you would like to contact Masticbest by phone or postal mail, please direct your questions and comments to:

Masticbest  Co.
P.O. Box  1 1 1,    Chios,   82 100

Phone:  +30 69 94 70 50 40  sms service available  24 hours


Privacy Policy:

We take the privacy of your information seriously. We will not disclose personal information without your permission. To process your order, certain service providers have access to your address, email and phone, but only for the purpose of completing the order and for internal tracking purposes. You will not be contacted by these service providers except in the case of questions or issues with your order.


mastic gum invoice

proforma invoice for mastic gum products


mastic mastiha paypal

mastic mastiha paypal http://www.masticbest.com


Page Created at 15  March  2010,

Last  Modified :   Today at – 09:00 a.m.   2015

© 2010 – © 2015 MasticBest All Rights Reserved


We update this blog daily.     Kαθημερινή ενημέρωση.


address  = masticbest

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Català: Llentiscle,Corsu: Listincu, lustincu,Deutsch: Mastix,Ελληνικά: Μαστίχα,Español: Lentisco, mata charneca,Français: Lentisque, pistachier lentisque,Italiano: Lentisco ·
,,ברית: אלת המסטיק
Lietuvių: Mastika,Nederlands: Mastiekboom,Norsk (bokmål): Mastik,Polski: Pistacja kleista,Sardu: Modditzi, moddizzi,Slovenčina: Mastix,Suomi: Mastiksipistaasi ,·Svenska: Mastixbuske,Tiếng Việt: Nhũ hương,Türkçe: Sakız ağacı,mastiha100@gmail.com
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Camphene, a Plant-Derived Monoterpene, Reduces Plasma Cholesterol and Triglycerides in Hyperlipidemic Rats Independently of HMG-CoA Reductase Activity

Ioanna Vallianou1, Nikolaos Peroulis1, Panayotis Pantazis2, Margarita Hadzopoulou-Cladaras


Background: Central to the pathology of coronary heart disease is the accumulation of lipids, cholesterol and triglycerides, within the intima of arterial blood vessels. The search for drugs to treat dislipidemia, remains a major pharmaceutical focus. In this study, we evaluated the hypolipidemic properties of the essential oil from Chios mastic gum (MGO).
Methodology/Principal Findings: The hypolipidemic effect of MGO was investigated in naı¨ve as well as in rats susceptible to detergent-induced hyperlipidemia. Serum cholesterol and triglycerides were determined using commercial kits. HMGCoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase activity was measured in HepG2 cell extracts using a radioactive assay; cellular cholesterol and cholesterol esters were assessed using gas chromatography. MGO administration into naıve rats resulted in a dose-dependent reduction in the constitutive synthesis of serum cholesterol and triglycerides. In hyperlipidemic rats, MGO treatment had also a strong hypolipidemic effect. By testing various components of MGO, we show for the first time that the hypolipidemic action is associated with camphene. Administration of camphene at a dose of 30 mg/gr of body weight in hyperlipidemic rats resulted in a 54.5% reduction of total cholesterol (p,0.001), 54% of Low Density Lipoprotein (LDL)-cholesterol (p,0.001) and 34.5% of triglycerides (p,0.001). Treatment of HepG2 cells with camphene led to a decrease in cellular cholesterol content to the same extend as mevinolin, a known HMG-CoA reductase inhibitor. The hypolipidemic action of camphene is independent of HMG-CoA reductase activity, suggesting that its hypocholesterolemic and hypotriglyceridemic effects are associated with a mechanism of action different than that of statins.
Conclusions: Given the critical role that the control of hyperlipidemia plays in cardiovascular disease, the results of our study provide insights into the use of camphene as an alternative lipid lowering agent and merits further evaluation.


Ever since antiquity, Chios mastiha has been well known for its medicinal and pharmaceutical properties.
Nowadays, it has been gradually revealed by the scientific community, through accurate and scientifically acceptable methods based on laboratory research and clinical studies carried out by independent researchers in Greece and abroad, that natural Chios mastiha is gifted with unique beneficial and therapeutic properties, thus confirming what has been historically recorded over the past.
To be more precise, scientific evidence has confirmed Mastiha’s beneficial action against disorders of the peptic system, its contribution to oral hygiene, its significant antimicrobial and anti-inflammatory action, as well as the fact that it constitutes a natural antioxidant agent. In addition to that, Chios mastiha contributes to wound healing and skin regeneration.
Reference is subsequently made to the most important research studies regarding Chios mastiha’s medicinal and pharmaceutical action, the results of which have been already published – as mentioned before – in international scientific journals.

  • Antimicrobial action of Chios Mastiha essential oil
    Significant research activity has been carried out regarding the antimicrobial action of mastiha’s essential oil – mastiha oil. Researchers have studied in particular that when mastiha oil, Chios mastiha essential oil, has been incorporated in the growth medium, it can delay the growth rate but also eliminate microbes, bacteria and pathogenic microorganisms.
    The results of such studies confirm the important antimicrobial and antifungal action of mastiha oil, thus encouraging its further usage as a component of pharmaceutical and other protection and care products.
  • Chios Mastiha as a protective agent against atherosclerosis
    Nowadays, there has been an intense scientific interest regarding the use of natural antioxidant agents as protective means against the atherosclerosis disease. Because of their composition, these substances offer protection against the formation of atheromatous plaques, thus preventing the risk of atherosclerosis and heart diseases. The presence of phenolic molecules, triterpenic compounds as well as phytosterols among Chios mastiha’s components is particularly important because of their action against the oxidation of low density lipoprotein (LDL) and that is a significant evidence for its potential antioxidant effect. Research activity in that field is still in an experimental stage. In any case, the results that have been published up to now are particularly encouraging and indicate a strong possibility of using mastiha as a natural antioxidant agent.
  • Chios Mastiha in relation to oral hygiene and dental research
    Scientific studies have proved that chewing Chios mastiha is very helpful for gum exercise, along with all its relevant beneficial effects in dental health. It has been further confirmed that Chios mastiha, unlike ordinary chewing gums, induces greater salivation due to its particular taste and its relative hardness, something that gives a greater feel of mouth freshness and cleanness, while it has been also proved to be relieving for people suffering from dry mouth, a disorder especially common among elderly persons.
    In addition, researchers have carried out numerous scientific and clinical studies regarding mastiha’s and Chios mastiha chewing gum’s action in decreasing microbial plaque formation and eliminating bacterial growth inside the oral cavity. Mastiha’s action in terms of prevention and treatment of peptic system diseases

The results of recent scientific studies related to mastiha’s therapeutic action



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